THIS IS THE POST OF THE CENTURY
She should have stabbed him
And again, Mexico is still America. Just for you to know…
Fucking asshole. What fucking right does he have to say that bullshit. Everyone in “America” is immigrated except for the native Americans. Dumbass.
Reblog this if gender dysphoria has ever seriously impacted your performance in school or work over the course of your life. Please just reblog, do not like this post. And only reblog it once, as liking or reblogging multiple times will throw off the numbers.
I’m trying to make a point to my mom that my gender dysphoria is not something I can just will myself past and it’s something that I need to take care of before anything else.
This is relevant to my life.
[from Trans Girl Diaries]This is fascinating!
Yay science \o/
The use of buccal cells is fascinating and I hope it progresses LOTS in the next year or so. IT WOULD BE NICE.
THIS IF FUCKING AMAZING.
hey rad fems + anti-sjws who hide behind “science” to justify their bigotry: check this fucking amazing shit out. check out this goddamn amazing science FUCK
Deep in the rainforests of the Indian state of Meghalaya, bridges are not built, they’re grown. For more than 500 years locals have guided roots and vines from the native Ficus Elastica (rubber tree) across rivers, using hollowed out trees to create root guidance systems. When the roots and vines reach the opposite bank they are allowed to take root. Some of the bridges are over 100 feet long and can support the weight of 50 people.
How do I make these?????????
Clever way of getting his features in there
Utilizing the critical thinking skills and greater levels of maturity assumed by my college degree, I deduced that I could make butt pancakes.
i wasnt gonna reblogg but then
Researchers have discovered a gene that regulates alcohol consumption and when faulty can cause excessive drinking. They have also identified the mechanism underlying this phenomenon.
The study showed that normal mice show no interest in alcohol and drink little or no alcohol when offered a free choice between a bottle of water and a bottle of diluted alcohol.
However, mice with a genetic mutation to the gene Gabrb1 overwhelmingly preferred drinking alcohol over water, choosing to consume almost 85% of their daily fluid as drinks containing alcohol - about the strength of wine.
The consortium of researchers from five UK universities – Newcastle University, Imperial College London, Sussex University, University College London and University of Dundee – and the MRC Mammalian Genetics Unit at Harwell, funded by the Medical Research Council (MRC), Wellcome Trust and ERAB, publish their findings today in Nature Communications.
Dr Quentin Anstee, Consultant Hepatologist at Newcastle University, joint lead author said: “It’s amazing to think that a small change in the code for just one gene can have such profound effects on complex behaviours like alcohol consumption.
“We are continuing our work to establish whether the gene has a similar influence in humans, though we know that in people alcoholism is much more complicated as environmental factors come into play. But there is the real potential for this to guide development of better treatments for alcoholism in the future.”
Identifying the gene for alcohol preference
Working at the MRC Mammalian Genetics Unit, a team led by Professor Howard Thomas from Imperial College London introduced subtle mutations into the genetic code at random throughout the genome and tested mice for alcohol preference. This led the researchers to identify the gene Gabrb1 which changes alcohol preference so strongly that mice carrying either of two single base-pair point mutations in this gene preferred drinking alcohol (10% ethanol v/v - about the strength of wine), over water.
The group showed that mice carrying this mutation were willing to work to obtain the alcohol-containing drink by pushing a lever and, unlike normal mice, continued to do so even over long periods. They would voluntarily consume sufficient alcohol in an hour to become intoxicated and even have difficulty in coordinating their movements.
The cause of the excessive drinking was tracked down to single base-pair point mutations in the gene Gabrb1, which codes for the beta 1 subunit, an important component of the GABAA receptor in the brain. This receptor responds to the brain’s most important inhibitory chemical messenger (GABA) to regulate brain activity. The researchers found that the gene mutation caused the receptor to activate spontaneously even when the usual GABA trigger was not present.
These changes were particularly strong in the region of the brain that controls pleasurable emotions and reward, the nucleus accumbens, as Dr Anstee explains: “The mutation of the beta1 containing receptor is altering its structure and creating spontaneous electrical activity in the brain in this pleasure zone, the nucleus accumbens. As the electrical signal from these receptors increases, so does the desire to drink to such an extent that mice will actually work to get the alcohol, for much longer than we would have expected.”
Professor Howard Thomas said: “We know from previous human studies that the GABA system is involved in controlling alcohol intake. Our studies in mice show that a particular subunit of GABAA receptor has a significant effect and most importantly the existence of these mice has allowed our collaborative group to investigate the mechanism involved. This is important when we come to try to modify this process first in mice and then in man.”
Leading to a treatment for alcohol addiction
Initially funded by the MRC, the 10-year project aimed to find genes affecting alcohol consumption. Professor Hugh Perry, Chair of the MRC’s Neurosciences and Mental Health Board, said: “Alcohol addiction places a huge burden on the individual, their family and wider society. There’s still a great deal we don’t understand about how and why consumption progresses into addiction, but the results of this long-running project suggest that, in some individuals, there may be a genetic component. If further research confirms that a similar mechanism is present in humans, it could help us to identify those most at risk of developing an addiction and ensure they receive the most effective treatment.”
A 2500 year old mummy that had some amazing tattoos.
NO FUCKING WAY.
YO HOLD ON.
IT GETS BETTER.
This mummy, found in the Altai mountains of Siberia, is actually that of a young woman who died at about the age of twenty-five; she is thought to have been a member of the Pazyryk tribe.
She was buried with six horses and two similarly-tattooed men (the horned griffon that decorates her shoulder also appears on the man buried closest to her, covering most of his right side), possibly escorts. She was also wearing a horse-hair wig, silk, and elaborate boots, which is all a level of ceremony that would have likely only been accorded to a woman of high rank. You didn’t get inked like this unless you were very important, and had worked your way up to that importance.
…Hence, of course, the references to her by researchers as ‘The Ukok Princess,’ although due to the lack of weapons in her grave they have concluded that the woman was in fact a healer or a storyteller.
And now I’m all consumed with curiosity: Who was she? What amazing things did she accomplish? Why these symbols, and what did they mean? Who were the two men alongside her?
The most informative article about it can be found here, although I would completely eat up any other information you guys could find.
woah woah woah this is neat
Scientists have long suspected that corvids – the family of birds including ravens, crows and magpies – are highly intelligent. Now, Tübingen neurobiologists Lena Veit und Professor Andreas Nieder have demonstrated how the brains of crows produce intelligent behavior when the birds have to make strategic decisions. Their results are published in the latest edition of Nature Communications.
Crows are no bird-brains. Behavioral biologists have even called them “feathered primates” because the birds make and use tools, are able to remember large numbers of feeding sites, and plan their social behavior according to what other members of their group do. This high level of intelligence might seem surprising because birds’ brains are constructed in a fundamentally different way from those of mammals, including primates – which are usually used to investigate these behaviors.
The Tübingen researchers are the first to investigate the brain physiology of crows’ intelligent behavior. They trained crows to carry out memory tests on a computer. The crows were shown an image and had to remember it. Shortly afterwards, they had to select one of two test images on a touchscreen with their beaks based on a switching behavioral rules. One of the test images was identical to the first image, the other different. Sometimes the rule of the game was to select the same image, and sometimes it was to select the different one. The crows were able to carry out both tasks and to switch between them as appropriate. That demonstrates a high level of concentration and mental flexibility which few animal species can manage – and which is an effort even for humans.
The crows were quickly able to carry out these tasks even when given new sets of images. The researchers observed neuronal activity in the nidopallium caudolaterale, a brain region associated with the highest levels of cognition in birds. One group of nerve cells responded exclusively when the crows had to choose the same image – while another group of cells always responded when they were operating on the “different image” rule. By observing this cell activity, the researchers were often able to predict which rule the crow was following even before it made its choice.
The study published in Nature Communications provides valuable insights into the parallel evolution of intelligent behavior. “Many functions are realized differently in birds because a long evolutionary history separates us from these direct descendants of the dinosaurs,” says Lena Veit. “This means that bird brains can show us an alternative solution out of how intelligent behavior is produced with a different anatomy.” Crows and primates have different brains, but the cells regulating decision-making are very similar. They represent a general principle which has re-emerged throughout the history of evolution. “Just as we can draw valid conclusions on aerodynamics from a comparison of the very differently constructed wings of birds and bats, here we are able to draw conclusions about how the brain works by investigating the functional similarities and differences of the relevant brain areas in avian and mammalian brains,” says Professor Andreas Nieder.
It was a lie